I vespri siciliani, originally conceived as a grand opéra for Paris, is one of Verdi’s most ambitious works, and the multi-faceted central role of Elena is one his most demanding: Callas is one of the few sopranos who have encompassed its vocal and dramatic diversity. This performance – conducted by Erich Kleiber and with Boris Christoff as the Sicilian activist Procida – took place in Florence in Spring 1951. Just over six months later, Callas opened the season at La Scala in the same opera. I vespri siciliani also served for her sole foray into directing opera, for the opening of the new Teatro Regio in Turin in 1973.

| Guido di Monforte: Enzo Mascherini |
| Il sire di Béthune: Bruno Carmassi |
| Il conte Vaudemont: Mario Frosini |
| Arrigo: Giórgios Kokoliós-Bardi |
| Giovanni da Procida: Boris Christoff |
| La duchessa Elena: Maria Callas |
| Ninetta: Mafalda Masini |
| Danieli: Gino Sarri |
| Tebaldo: Aldo De Paoli |
| Roberto: Lido Pettini |
| Manfredo: Brenno Ristori |